Red Flags to Be Aware Of
These disorders can lead to a variety of symptoms, often appearing in infancy or early childhood. To help, there's DOJOLVI, a prescription medication used to treat long-chain fatty acid oxidation disorders (LC-FAOD).
Common Signs of LC-FAODs
Low Energy Levels
One of the earliest signs of LC-FAODs is low energy or fatigue. Children with this condition may appear unusually tired or lethargic, especially after physical activity.
Hypoglycemia (Low Blood Sugar)
Individuals may experience low blood sugar, leading to symptoms like dizziness, confusion or irritability. This can occur during fasting or illness.
Muscle Weakness
Muscle weakness is common, particularly after exercise. Affected individuals may struggle with physical activities that require strength and endurance.
Recurrent Episodes of Vomiting
Frequent vomiting can be a sign of an energy crisis in people with LC-FAODs. This can happen during illness or when they don't eat for a while.
Cardiac Issues
Some individuals may develop heart problems, such as cardiomyopathy. This condition affects the heart muscle, leading to various cardiovascular symptoms.
Liver Problems
Enlarged liver (hepatomegaly) can occur, and affected individuals may have abnormal liver function tests. This can lead to additional health concerns.
Seizures
Seizures can occur, particularly during times of stress or illness when the body needs more energy. This is a serious symptom that requires immediate medical attention.
Growth Delays
Children with LC-FAODs may experience delayed growth or development compared to their peers. This can include delayed milestones such as sitting, walking or talking.
Sensitivity to Fasting
Many people with LC-FAODs cannot go long periods without food. Symptoms may worsen with fasting, and regular meals are essential.
Muscle Pain
Some individuals report muscle pain or discomfort, particularly after exercise. This is often due to the body’s inability to properly use fats for energy.
Treatments for LC-FAODs
While there is no cure for LC-FAODs, various treatments can help manage symptoms and improve quality of life. Here are some common treatment options:
Dietary Changes
A low-fat, high-carbohydrate diet is often recommended. This helps prevent symptoms by reducing the need for fat metabolism.
Frequent Meals
Eating smaller, more frequent meals can help maintain stable energy levels and prevent hypoglycemia.
Supplementation
Medium-chain triglycerides (MCTs) may be used as an alternative energy source. MCTs are easier to digest and do not require the same metabolic process as long-chain fats.
Emergency Protocols
Having an emergency plan is crucial. This may include medications or glucose solutions to manage hypoglycemic episodes.
Regular Monitoring
Regular check-ups with healthcare providers are essential. Monitoring blood sugar levels and overall health can help detect issues early.
Supportive Therapies
Physical therapy may help with muscle strength and endurance. Occupational therapy can assist with daily living skills, particularly for children.
Genetic Counseling
Families may benefit from genetic counseling to understand the condition better and discuss future family planning options.
DOJOLVI
DOJOLVI (triheptanoin) is a prescription medication used to treat long-chain fatty acid oxidation disorders (LC-FAOD). It helps to provide energy and reduce the risk of metabolic complications associated with LC-FAOD, improving overall energy levels and quality of life.
Understanding the Signs
If you notice any signs of LC-FAODs in yourself or a loved one, it is essential to consult a healthcare professional for diagnosis and appropriate management. Early intervention can significantly improve outcomes and quality of life for individuals with this condition.